Desmoglein 1

Identifiers

DSG1; CDHF4; DG1; DSG; PPKS1; SPPK1

External IDs

OMIM: 125670 MGI: 94930 HomoloGene: 1463 GeneCards: DSG1 Gene

Gene Ontology
Molecular function	• calcium ion binding • toxic substance binding • gamma-catenin binding
Cellular component	• cytosol • plasma membrane • cell-cell junction • internal side of plasma membrane • integral to membrane • apical plasma membrane • lateral plasma membrane • desmosome
Biological process	• apoptotic process • cellular component disassembly involved in execution phase of apoptosis • cell-cell junction assembly • homophilic cell adhesion • cell-cell adhesion • calcium-dependent cell-cell adhesion • response to progesterone stimulus • protein stabilization • maternal process involved in female pregnancy
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 18:
28.9 – 28.94 Mb

Chr 18:
20.31 – 20.34 Mb

PubMed search

[1]

[2]

Desmoglein 1 is a protein that in humans is encoded by the DSG1 gene.^[1]^[2]

Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.^[2]

Interactions [edit]

Desmoglein 1 has been shown to interact with PKP3,^[3]PKP2,^[4] and PTPRT(PTPrho)^[5]

References [edit]

^ Arnemann J, Spurr NK, Wheeler GN, Parker AE, Buxton RS (Oct 1991). "Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)". Genomics 10 (3): 640–5. doi:10.1016/0888-7543(91)90446-L. PMID 1889810.
^ ^a ^b "Entrez Gene: DSG1 desmoglein 1".
^ Bonné, Stefan; Gilbert Barbara, Hatzfeld Mechthild, Chen Xinyu, Green Kathleen J, van Roy Frans (Apr. 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. (United States) 161 (2): 403–16. doi:10.1083/jcb.200303036. ISSN 0021-9525. PMC 2172904. PMID 12707304.
^ Chen, Xinyu; Bonne Stefan, Hatzfeld Mechthild, van Roy Frans, Green Kathleen J (Mar. 2002). "Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling". J. Biol. Chem. (United States) 277 (12): 10512–22. doi:10.1074/jbc.M108765200. ISSN 0021-9258. PMID 11790773.
^ Besco JA, Hooft van Huijsduijnen R, Frostholm A, Rotter A (2006). "Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT).". Brain Res 1116 (1): 50–7. doi:10.1016/j.brainres.2006.07.122. PMID 16973135.

Further reading [edit]

Amagai M (2003). "Desmoglein as a target in autoimmunity and infection". J. Am. Acad. Dermatol. 48 (2): 244–52. doi:10.1067/mjd.2003.7. PMID 12582396.
Wheeler GN, Parker AE, Thomas CL (1991). "Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules". Proc. Natl. Acad. Sci. U.S.A. 88 (11): 4796–800. doi:10.1073/pnas.88.11.4796. PMC 51753. PMID 1711210.
Amagai M, Klaus-Kovtun V, Stanley JR (1992). "Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion". Cell 67 (5): 869–77. doi:10.1016/0092-8674(91)90360-B. PMID 1720352.
Martínez RD (1992). "[Characterization of the desmoglein in renal cells in culture]" [Characterization of the desmoglein in renal cells in culture]. Revista alergia México (in Spanish) 38 (2): 59–64. PMID 1754823.
Nilles LA, Parry DA, Powers EE (1992). "Structural analysis and expression of human desmoglein: a cadherin-like component of the desmosome". J. Cell. Sci. 99 (4): 809–21. PMID 1770008.
Roh JY, Stanley JR (1995). "Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment". J. Invest. Dermatol. 104 (5): 720–4. doi:10.1111/1523-1747.ep12606963. PMID 7738346.
Simrak D, Cowley CM, Buxton RS, Arnemann J (1995). "Tandem arrangement of the closely linked desmoglein genes on human chromosome 18". Genomics 25 (2): 591–4. doi:10.1016/0888-7543(95)80067-V. PMID 7790000.
Wang Y, Amagai M, Minoshima S (1994). "The human genes for desmogleins (DSG1 and DSG3) are located in a small region on chromosome 18q12". Genomics 20 (3): 492–5. doi:10.1006/geno.1994.1207. PMID 8034325.
Schäfer S, Koch PJ, Franke WW (1994). "Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins". Exp. Cell Res. 211 (2): 391–9. doi:10.1006/excr.1994.1103. PMID 8143788.
Adams MJ, Reichel MB, King IA (1998). "Characterization of the regulatory regions in the human desmoglein genes encoding the pemphigus foliaceous and pemphigus vulgaris antigens". Biochem. J. 329 (Pt 1): 165–74. PMC 1219028. PMID 9405290.
Marcozzi C, Burdett ID, Buxton RS, Magee AI (1998). "Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion". J. Cell. Sci. 111 (4): 495–509. PMID 9443898.
Smith EA, Fuchs E (1998). "Defining the Interactions Between Intermediate Filaments and Desmosomes". J. Cell Biol. 141 (5): 1229–41. doi:10.1083/jcb.141.5.1229. PMC 2137181. PMID 9606214.
Rickman L, Simrak D, Stevens HP (1999). "N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma". Hum. Mol. Genet. 8 (6): 971–6. doi:10.1093/hmg/8.6.971. PMID 10332028.
Li G, Schaider H, Satyamoorthy K (2002). "Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development". Oncogene 20 (56): 8125–35. doi:10.1038/sj.onc.1205034. PMID 11781826.
Chen X, Bonne S, Hatzfeld M (2002). "Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling". J. Biol. Chem. 277 (12): 10512–22. doi:10.1074/jbc.M108765200. PMID 11790773.
Martel P, Gilbert D, Busson M (2003). "Epistasis between DSG1 and HLA class II genes in pemphigus foliaceus". Genes Immun. 3 (4): 205–10. doi:10.1038/sj.gene.6363839. PMID 12058255.
Hanakawa Y, Schechter NM, Lin C (2002). "Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome". J. Clin. Invest. 110 (1): 53–60. doi:10.1172/JCI15766. PMC 151035. PMID 12093888.
Hanakawa Y, Amagai M, Shirakata Y (2003). "Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation". J. Invest. Dermatol. 119 (6): 1231–6. doi:10.1046/j.1523-1747.2002.19648.x. PMID 12485422.

This article on a gene on chromosome 18 is a stub. You can help Wikipedia by expanding it.

Membrane proteins: cell adhesion molecules

Calcium-independent

IgSF CAM	N-CAM (Myelin protein zero) ICAM (1, 5) VCAM-1 PE-CAM L1-CAM Nectin (PVRL1, PVRL2, PVRL3)

Integrins	LFA-1 (CD11a+CD18) Integrin alphaXbeta2 (CD11c+CD18) Macrophage-1 antigen (CD11b+CD18) VLA-4 (CD49d+CD29) Glycoprotein IIb/IIIa (ITGA2B+ITGB3)

Calcium-dependent

Cadherins

Classical	CDH1 CDH2 CDH3

Desmosomal	Desmoglein (DSG1, DSG2, DSG3, DSG4) Desmocollin (DSC1, DSC2, DSC3)

Protocadherin	PCDH1

Unconventional/ungrouped	T-cadherin CDH4 CDH5 CDH6 CDH8 CDH11 CDH12 CDH15 CDH16 CDH17 CDH9 CDH10

Selectins

Other

See also: cell membrane protein disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr

Desmoglein 1

Contents

Interactions [edit]

See also [edit]

References [edit]

Further reading [edit]

Related Links