In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.
^Takeda, Atsunobu; Hamano Shinjiro, Yamanaka Atsushi, Hanada Toshikatsu, Ishibashi Tatsuro, Mak Tak W, Yoshimura Akihiko, Yoshida Hiroki (May. 2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment". J. Immunol. (United States) 170 (10): 4886–90. ISSN0022-1767. PMID12734330.
Sprecher CA, Grant FJ, Baumgartner JW, et al. (1998). "Cloning and characterization of a novel class I cytokine receptor.". Biochem. Biophys. Res. Commun.246 (1): 82–90. doi:10.1006/bbrc.1998.8576. PMID9600072.
Chen Q, Ghilardi N, Wang H, et al. (2000). "Development of Th1-type immune responses requires the type I cytokine receptor TCCR.". Nature407 (6806): 916–20. doi:10.1038/35038103. PMID11057672.
Pflanz S, Timans JC, Cheung J, et al. (2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.". Immunity16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID12121660.
Takeda A, Hamano S, Yamanaka A, et al. (2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment.". J. Immunol.170 (10): 4886–90. PMID12734330.