List of IARC Group 2B carcinogens
This article is outdated . Please update this article to reflect recent events or newly available information. (June 2012)
Substances, mixtures and exposure circumstances in this list have been classified by the International Agency for Research on Cancer (IARC) as Group 2B : The agent (mixture) is possibly carcinogenic to humans. The exposure circumstance entails exposures that are possibly carcinogenic to humans. This category is used for agents, mixtures and exposure circumstances for which there is limited evidence of carcinogenicity in humans and less than sufficient evidence of carcinogenicity in experimental animals. It may also be used when there is inadequate evidence of carcinogenicity in humans but there is sufficient evidence of carcinogenicity in experimental animals. In some instances, an agent, mixture or exposure circumstance for which there is inadequate evidence of carcinogenicity in humans but limited evidence of carcinogenicity in experimental animals together with supporting evidence from other relevant data may be placed in this group. Further details can be found in the IARC Monographs .
Agents and groups of agents [edit ]
A-a-C (2-Amino-9H-pyrido[2,3-b ]indole)
Acetaldehyde
Acetamide
Acrylonitrile
Adapalene
AF-2 (2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide)
Aflatoxin M1
para -Aminoazobenzene
ortho-Aminoazotoluene
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole
Amsacrine
ortho-Anisidine
Antimony trioxide
Aramite
Auramine (technical-grade)
Azaserine
Aziridine
Benz[j ]aceanthrylene
Benz[a ]anthracene
Benzo[b ]fluoranthene
Benzo[j ]fluoranthene
Benzo[k ]fluoranthene
Benzo[c ]phenanthrene
Benzofuran
Benzyl violet 4B
2,2-Bis(bromomethyl)propane-1,3-diol
Bleomycin
Bracken fern
Bromodichloromethane
Butylated hydroxyanisole
b-Butyrolactone
Caffeic acid
Carbon black
Carbon tetrachloride
Catechol
Chlordane
Chlordecone (Kepone)
Chlorendic acid
para -Chloroaniline
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone
Chloroform
1-Chloro-2-methylpropene
Chlorophenoxy herbicides
4-Chloro-ortho-phenylenediamine
Chloroprene
Chlorothalonil
Chrysene
CI Acid Red 114
CI Basic Red 9
CI Direct Blue 15
Citrus Red No. 2
Cobalt and cobalt compounds 1
Cobalt sulfate and other soluble cobalt(II) salts
Coconut oil diethanolamine condensate
para-Cresidine
Cycasin
Dacarbazine
Dantron (Chrysazin, 1,8-Dihydroxyanthraquinone)
Daunomycin
DDT (p ,p' -DDT)
N,N'-Diacetylbenzidine
2,4-Diaminoanisole
4,4'-Diaminodiphenyl ether
2,4-Diaminotoluene
Dibenz[a,h ]acridine
Dibenz[a,j ]acridine
7H -Dibenzo[c,g ]carbazole
Dibenzo[a,e ]pyrene
Dibenzo[a,h ]pyrene
Dibenzo[a,i ]pyrene
1,2-Dibromo-3-chloropropane
2,3-Dibromopropan-1-ol
Dichloroacetic acid
para-Dichlorobenzene
3,3'-Dichlorobenzidine
3,3'-Dichloro-4,4'-diaminodiphenyl ether
1,2-Dichloroethane
Dichloromethane (methylene chloride)
1,3-Dichloropropene (technical grade)
Dichlorvos
1,2-Diethylhydrazine
Diglycidyl resorcinol ether
Dihydrosafrole
Diisopropyl sulfate
3,3'-Dimethoxybenzidine (o -Dianisidine)
para-Dimethylaminoazobenzene
trans -2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)-vinyl]-1,3,4-oxadiazole
2,6-Xylidine (2,6-Dimethylaniline)
3,3'-Dimethylbenzidine (o -Tolidine)
1,1-Dimethylhydrazine
3,7-Dinitrofluoranthene
3,9-Dinitrofluoranthene
1,6-Dinitropyrene
1,8-Dinitropyrene
2,4-Dinitrotoluene
2,6-Dinitrotoluene
1,4-Dioxane
Disperse Blue 1
1,2-Epoxybutane
Ethyl acrylate
Ethylbenzene
Ethylene dichloride
Ethyl methanesulfonate
Foreign bodies, implanted in tissues
Polymeric, prepared as thin smooth films (with the exception of poly(glycolic acid))
Metallic, prepared as thin smooth films
Metallic cobalt, metallic nickel and an alloy powder containing 66-67% nickel, 13-16% chromium and 7% iron
2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole
Fumonisin B1
Furan
Glu-P-1 (2-Amino-6-methyldipyrido[1,2-a :3',2'-d ]imidazole)
Glu-P-2 (2-Aminodipyrido[1,2-a :3',2'-d ]imidazole)
Glycidaldehyde
Griseofulvin
HC Blue No. 1
Heptachlor
Hexachlorobenzene
Hexachloroethane
Hexachlorocyclohexanes
Hexamethylphosphoramide (HMPA)
Human immunodeficiency virus type 2 (infection with)
Human papillomaviruses : some types other than 16, 18, 31 and 33
Hydrazine
1-Hydroxyanthraquinone
Indeno[1,2,3-cd ]pyrene
Iron-dextran complex
Isoprene
Lasiocarpine
Lead
Magnetic fields (extremely low frequency )
MeA-a-C (2-Amino-3-methyl-9H -pyrido[2,3-b ]indole)
Medroxyprogesterone acetate
MeIQ (2-Amino-3,4-dimethylimidazo[4,5-f ]quinoline)
MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f ]quinoxaline)
Merphalan
2-Methylaziridine (Propyleneimine)
Methylazoxymethanol acetate
5-Methylchrysene
4,4'-Methylene bis(2-methylaniline)
4,4'-Methylenedianiline
Methylmercury compounds 1
2-Methyl-1-nitroanthraquinone (uncertain purity)
N-Methyl-N-nitrosourethane
Methylthiouracil
Metronidazole
Michler's base (4,4'-methylene-bis(N ,N -dimethyl)benzenamine)
Michler's ketone (4,4'-bis(dimethylamino)benzophenone)
Microcystin-LR
Mirex
Mitomycin C
Mitoxantrone
Monocrotaline
5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)amino]-2-oxazolidinone
Nafenopin
Naphthalene
Nickel , metallic and alloys
Niridazole
Nitrilotriacetic acid and its salts 1
5-Nitroacenaphthene
2-Nitroanisole
Nitrobenzene
6-Nitrochrysene
Nitrofen (technical-grade)
2-Nitrofluorene
1-[(5-Nitrofurfurylidene)amino]-2-imidazolidinone
N -[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide
Nitrogen mustard N -oxide
Nitromethane
2-Nitropropane
1-Nitropyrene
4-Nitropyrene
N-Nitrosodi-n-butylamine
N-Nitrosodiethanolamine
N-Nitrosodi-n-propylamine
3-(N-Nitrosomethylamino)propionitrile
N-Nitrosomethylethylamine
N-Nitrosomethylvinylamine
N-Nitrosomorpholine
N-Nitrosopiperidine
N-Nitrosopyrrolidine
N-Nitrososarcosine
Ochratoxin A
Oestrogen-progestogen therapy, postmenopausal
Oil Orange SS
Oxazepam
Palygorskite (attapulgite) (long fibres, >5 µm)
Panfuran S (containing dihydroxymethylfuratrizine)
Phenazopyridine hydrochloride
Phenobarbital
Phenolphthalein
Phenoxybenzamine hydrochloride
Phenyl glycidyl ether
Phenytoin
PhIP (2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine )
Polychlorophenols and their sodium salts (mixed exposures)
Ponceau MX
Ponceau 3R
Potassium bromate
Progestins
Progestogen-only contraceptives
1,3-Propane sultone
β-Propiolactone
Propylene oxide
Propylthiouracil
Radiofrequency electromagnetic fields , such as, but not limited to, those associated with wireless phones [ 1]
Refractory ceramic fibres
Riddelliine
Safrole
Schistosoma japonicum (infection with)
Sodium ortho -phenylphenate
Special-purpose fibres such as E-glass and '475' glass fibres
Sterigmatocystin
Streptozotocin
Styrene
Sulfallate
Tetrafluoroethylene
Tetranitromethane
Thioacetamide
4,4'-Thiodianiline
Thiouracil
Titanium dioxide
Toluene diisocyanates
Trichlormethine (Trimustine hydrochloride)
Trp-P-1 (3-Amino-1,4-dimethyl-5H -pyrido[4,3-b ]indole)
Trp-P-2 (3-Amino-1-methyl-5H -pyrido[4,3-b ]indole)
Trypan blue
Uracil mustard
Vanadium pentoxide
Vinyl acetate
4-Vinylcyclohexene
4-Vinylcyclohexene diepoxide
Zalcitabine
Zidovudine (AZT)
Mixtures [edit ]
Exposure circumstances [edit ]
^1 Evaluated as a group.
^2 There is some evidence of an inverse relationship between coffee drinking and cancer of the large bowel; coffee drinking could not be classified as to its carcinogenicity to other organs.
External links [edit ]
References [edit ]
^ Press release No 208, 31 May 2011 , IARC classifies Radiofrequency Electromagnetic Fields as possibly carcinogenic to humans
Main articles
Major suspected carcinogens
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