TNP1

Transition protein 1 (during histone to protamine replacement)

Identifiers

External IDs

OMIM: 190231 MGI: 98784 HomoloGene: 2465 GeneCards: TNP1 Gene

Gene Ontology
Molecular function	• DNA binding
Cellular component	• nucleosome • male germ cell nucleus
Biological process	• single strand break repair • nucleosome disassembly • chromatin remodeling • chromatin silencing • multicellular organismal development • spermatid development • spermatid nucleus differentiation • spermatid nucleus elongation • sexual reproduction • sperm motility • fertilization, exchange of chromosomal proteins • negative regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
217.72 – 217.72 Mb

Chr 1:
73.02 – 73.02 Mb

PubMed search

[1]

[2]

Spermatid nuclear transition protein 1 is a protein that in humans is encoded by the TNP1 gene.^[1]^[2]

References [edit]

^ Luerssen H, Mattei MG, Schroter M, Grzeschik KH, Adham IM, Engel W (Jan 1991). "Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2". Genomics 8 (2): 324–30. doi:10.1016/0888-7543(90)90289-7. PMID 2249851.
^ "Entrez Gene: TNP1 transition protein 1 (during histone to protamine replacement)".

Further reading [edit]

Meistrich ML, Mohapatra B, Shirley CR, Zhao M (2004). "Roles of transition nuclear proteins in spermiogenesis.". Chromosoma 111 (8): 483–8. doi:10.1007/s00412-002-0227-z. PMID 12743712.
Chirat F, Martinage A, Briand G, et al. (1991). "Nuclear transition protein 1 from ram elongating spermatids. Mass spectrometric characterization, primary structure and phosphorylation sites of two variants.". Eur. J. Biochem. 198 (1): 13–20. doi:10.1111/j.1432-1033.1991.tb15980.x. PMID 2040274.
Baskaran R, Rao MR (1991). "Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1.". J. Biol. Chem. 265 (34): 21039–47. PMID 2250010.
Kleene KC, Borzorgzadeh A, Flynn JF, et al. (1988). "Nucleotide sequence of a cDNA clone encoding mouse transition protein 1.". Biochim. Biophys. Acta 950 (2): 215–20. PMID 3382664.
Luerssen H, Hoyer-Fender S, Engel W (1988). "The nucleotide sequence of human transition protein 1 cDNA.". Nucleic Acids Res. 16 (15): 7723. doi:10.1093/nar/16.15.7723. PMC 338445. PMID 3412903.
Akama K, Kojima S, Nakano M, et al. (1994). "The amino acid sequence and phosphorylation sites of a boar transition protein 1.". Biochem. Mol. Biol. Int. 32 (2): 349–57. PMID 8019440.
Steger K, Klonisch T, Gavenis K, et al. (1999). "Expression of mRNA and protein of nucleoproteins during human spermiogenesis.". Mol. Hum. Reprod. 4 (10): 939–45. doi:10.1093/molehr/4.10.939. PMID 9809674.
Yu YE, Zhang Y, Unni E, et al. (2000). "Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4683–8. doi:10.1073/pnas.97.9.4683. PMC 18293. PMID 10781074.
Siffroi JP, Alfonsi MF, Dadoune JP (2001). "Electron microscopic in situ hybridization study of simultaneous expression of TNP1 and PRM1 genes in human spermatids.". Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia 103 (4 Suppl 1): 65–74. PMID 11315969.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Miyagawa Y, Nishimura H, Tsujimura A, et al. (2006). "Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations.". J. Androl. 26 (6): 779–86. doi:10.2164/jandrol.05069. PMID 16291974.
Jedrzejczak P, Kempisty B, Bryja A, et al. (2007). "Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men.". Arch. Androl. 53 (4): 199–205. doi:10.1080/01485010701426430. PMID 17852044.

This article on a gene on chromosome 2 is a stub. You can help Wikipedia by expanding it.

v t e Structures of the cell nucleus / nuclear protein

Envelope (membrane)/ nuclear lamina	Pore complex: Nucleoporin (NUP35, NUP37, NUP43, NUP50, NUP54, NUP62, NUP85, NUP88, NUP93, NUP98, NUP107, NUP133, NUP153, NUP155, NUP160, NUP188, NUP205, NUP210, NUP214) · AAAS

Nucleolus	Cajal (coiled) body (GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, SMN/SIP1, COIL) · Perinucleolar compartment (PTBP1, CUGBP1) TCOF · ATXN7

Other	Chromatin · Dot (PML body) · Paraspeckle SMC protein: Cohesin (SMC1A, SMC1B, SMC3) · Condensin (NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NCAPH2, SMC2, SMC4) · DNA repair (SMC5, SMC6) Transition nuclear protein: TNP1, TNP2 Nuclear matrix · Nucleoplasm · Nucleoskeleton · Nucleosol LITAF see also transcription factors and intracellular receptors

see also nucleus diseases B strc: edmb (perx), skel (ctrs), epit, cili, mito, nucl (chro)

TNP1

References [edit]

Further reading [edit]

Related Links